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The Original Xenograft Bone Substitute

Still Exactly Like No Other


About Geistlich Bio-Oss®

The leading xenogeneic bone substitute in regenerative dentistry worldwide.1,2

  • The osteo-conductive properties lead to effective and predictable bone regeneration3‑5
  • Easy to apply and can be used in a variety of therapeutic areas
  • Documented in more than 1200 publications
  • Long-term data demonstrates predictable results in Guided Bone Regeneration treatments used in combination with Geistlich Bio-Gide®6


Geistlich Bio-Oss® becomes fully integrated into living bone over time to maintain space and preserve regenerative volume7,8

Human bone shows a unique structure. (Magnification 50x)

In the production of Geistlich Bio-Oss®, derived from bovine bone, these complex tissues are reduced to their essential form. The native crystalline structure, which is highly similar to human bone, is preserved through our unique, patented technology.


Geistlich Bio-Oss® has excellent handling properties and provides predictable results in daily clinical use

  • Hydrophilic properties promote rapid and complete hydration
  • Easily modeled and adheres optimally to the walls of the defect
  • Subsequent application of Geistlich Bio-Gide®, a collagen membrane, enables undisturbed healing which leads to new bone regeneration

Treatment made simple

A pre-filled syringe containing Geistlich Bio-Oss® granules

  • Easy-to-use applicator for faster application, precision and convenience
  • Greater flexibility in a variety of clinical situations
  • Available in both large and small particles
  • Optimal access that allows easy placement into posterior defects

Geistlich Bio-Oss®
Geistlich Bio-Oss Pen®

“As a researcher, it is interesting to test new products and materials. However, as a healthcare provider, it is imperative that I use a dependable and trustworthy product on my patients and as a teacher, it is critical to be an honest and reliable mentor. This is why after 30+ years in clinical practice and teaching undergraduate and postgraduate residents, I rely on Bio-Oss®. My reputation depends on it!”

– Dr. Peter K. Moy | Los Angeles, California, USA

“Unique properties make Geistlich Bio-Oss® the ideal biomaterial for long-term volume preservation.”

– Professor Daniel Buser | Berne, Switzerland

“Geistlich Bio-Oss® has been found to provide more stable radiographic bone fill than autologous bone.”

– Dr. Avinash Bidra | Farmington, Connecticut, USA

Frequently Asked Questions

When do you use the large Geistlich Bio-Oss® particles (1-2 mm) and when do you use the small particles (0.25-1 mm)?

Fundamentally, the use of small particles is recommended for small defects (up to 2 dental alveoli) and for augmenting autogenous grafts. The large particles are recommended for large defects (> 2 dental alveoli, sinus lifts), however, preferences can vary from dentist to dentist.

Can Geistlich Bio-Oss® or Geistlich Bio-Oss Pen® also be used without membrane?

A membrane should be used in conjunction with Geistlich Bio-Oss® or Geistlich Bio-Oss Pen® as a barrier against the ingrowth of soft tissue1. Native collagen membranes such as Geistlich Bio-Gide® also promote wound healing and increase therapeutic safety in the event of a postoperative wound dehiscence2,3. Clinicians should read the package insert prior to use.

  1. Gielkens PF, et al.: Clin Oral Implants Res 2008; 19(5) : 516-21. 
  2. Tal H, et al.: Clin Oral Implants Res 2008; 19(3): 295-302. 
  3. Becker J, et al.: Clin Oral Implants Res 2009; 20(7): 742-49

Can Geistlich Bio-Oss® or Geistlich Bio-Oss Pen® be re-sterilized?

No. If Geistlich Bio-Oss® is autoclaved, moisture can collect in the particles due to the high porosity of the product, which can change the hydrophilic properties. Moreover, Geistlich Bio-Oss® is not approved for re-sterilization. Re-sterilization under any circumstances is not recommended.

Should Geistlich Bio-Oss® be mixed with antibiotics?

The use of local antibiotics is generally unnecessary when utilizing Geistlich Bio-Oss®.

Is Geistlich Bio-Oss® safe (transmission of diseases such as Bovine Spongiform Encepholapathy (BSE)?

Geistlich Bio-Oss® is made from the mineral part of bovine bone. The strictly controlled manufacturing process ensures high quality and safety standards by:

  • country of origin: Australia (and for some countries also New Zealand) which is historically and currently free of BSE
  • defined origin of the raw material
  • selected and certified slaughterhouses
  • pre- and post-mortem health inspection for each individual animal
  • extremity bone (according to WHO Guideline on tissue infectivity classified as tissues with no detected infectivity or infectious prions)
  • effective inactivation methods with 15h treatment at high temperature and cleaning with strong alkaline solutions
  • sterilization, double sterile packaging
  • official controls by international authorities

Do I have to use venous blood or can I use blood from the defect?

Blood from the defect may be used for mixing. Care should be taken to avoid contamination with salivary bacteria.

How much saline or blood is needed to moisten the Geistlich Bio-Oss Pen®?

0.25 cc Geistlich Bio-Oss Pen®: ~0.25 ml
0.5 cc Geistlich Bio-Oss Pen®: ~0.5 ml

How many Geistlich Bio-Oss Pen® delivery systems are needed for a sinus floor elevation?

Depending on the size of the defect, between 1.5 to 4 cc of Geistlich Bio-Oss® granules are needed, 3cc on average.

Can the Geistlich Bio-Oss® granules be mixed with autologous bone in the Geistlich Bio-Oss Pen®?

No, Geistlich does not recommend mixing autologous bone with the Geistlich Bio-Oss® granules within the syringe.

If the applicator tip is contaminated (e.g. has fallen on the floor) can it be re-used?

No. Discard and use a new Geistlich Bio-Oss Pen®.

Can separate applicator tips be ordered?

No. The applicator tips are not available separately.

Are other applicator tips (forms, length, diameter) available?

No. There are no other tips available.

  1. iData Research Inc., US Dental Bone Graft Substitutes and other Biomaterials Market, 2022.
  2. iData Inc., European Dental Bone Graft Substitutes and other Biomaterials Market, 2015.
  3. Orsini G, et al.: J Biomed Mater Res, B: Appl Biomater 2005;74(1): 448-57.
  4. Jung RE, et al.: Clin Oral Implants Res 2013; 24(10): 1065-73.
  5. Aghaloo TL, Moy PK.: Int J Oral Maxillofac Implants 2007; 22 Suppl: 49-70.
  6. Jung RE, et al.: Clin Oral Implants Res. 2013; 24(10):1065-73.
  7. Galindo-Moreno, P. et al. (2014). Clin Oral Implants Res.25(3):366-71.
  8. Araújo, MG. et al. (2010). Clin Oral Implants Res. 21(1):55-64.