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  • Geistlich Bio-Gide®

    Geistlich Bio-Gide®
    1-20151

  • Bio-Gide® Compressed

    Bio-Gide® Compressed
    1-500363

  • Geistlich Bio-Gide® Shape

    Geistlich Bio-Gide® Shape
    500377

  • Geistlich Bio-Gide® Perio

    Geistlich Bio-Gide® Perio
    20148

  • Geistlich Perio-System Combi-Pack

    Geistlich Perio-System Combi-Pack
    20147

  • Geistlich Combi-Kit Collagen

    Geistlich Combi-Kit Collagen
    20146

Intelligently Designed to Guide Your Success

PRODUCT INFORMATION

About Geistlich Bio-Gide®

The leading collagen membrane in North America for oral tissue regeneration1,2

  • Porcine, resorbable collagen membrane with excellent tissue integration3,4
  • Validated by 25 years of successful clinical use
  • Documented in more than 350 publications
  • Long-term data demonstrates predictable results in Guided Bone Regeneration treatments used in combination with Geistlich Bio-Oss®5

UNIQUE PROPERTIES

Intelligently Designed Structures

  • Permits prompt and homogeneous vascularization through its bilayered, natural collagen structure 
  • Offers optimal tissue integration and wound stabilization6
  • Allows for open healing when primary closure cannot be achieved 
  • Compares favorably with fewer dehiscences to other available membranes7-9
  • Prevents soft tissue ingrowth and serves as a scaffold for the attachment of fibroblasts10-14

HANDLING & EASE OF USE

A biocompatible membrane with unsurpassed handling and documented regenerative success

  • Easily trims to the defect size and shape
  • Applies dry and moistens rapidly in situ
  • Excellent hydrophilicity promotes adhesion to the graft and surrounding bone
  • High tensile strength prevents tearing during handling

Handling Geistlich Bio-Gide®

Handling Geistlich Bio-Gide Perio®

Extended Product Range

Geistlich Bio-Gide Shape®

  • Convenient – Developed and shaped specifically for non-intact extraction sockets
  • Pre-Trimmed – Reduces preparation time
  • Handling – Slower uptake of moisture prolongs the time available for the exact positioning of the material
  • Uneventful wound healing – in an open healing situation

Geistlich Bio-Gide Compressed®

  • An alternative handling option
  • Designed to suit your personal handling preference
  • Compressed membrane with a smoother surface

Geistlich Bio-Gide Perio®

  • A smoother upper surface slows the absorption of moisture and lengthens the time available for exact positioning into the defect
  • Firmer material facilitates trimming when dry
  • Easy customization with 4 sterile templates

Geistlich Bio-Gide®

SHOP NOW

“The Geistlich Bio-Gide®membrane has, for 20 years, proven itself to be reliable and is characterized by easy clinical handling and a low complication rate.”

– Professor Daniel Buser | Berne, Switzerland

“When performing vertical GBR using PTFE membranes, I additionally use Geistlich Bio-Gide® to enable complete coverage of all the particles (autogenous and Geistlich Bio-Oss®) in proximity of the adjacent teeth.”

– Dr. Isabella Rocchietta | London, England

“I have used Geistlich Bio-Gide® in combination with non-perforated PTFE TR-membranes for vertical and horizontal GBR over the last 25 years. It acts as extra protection for the periphery of the bone graft mix, sealing the borders of the grafted site, which may be otherwise compromised.”

– Dr. Sascha A. Jovanovic | Los Angeles, California, USA

“I have used Geistlich Bio-Gide® on top of the perforated membrane in over 100 cases. The rationale is to filter out fibroblast in-growth at the same time allowing transvascularization to take place.”

– Prof. Dr. Istvan Urban | Budapest, Hungary

“Geistlich Bio-Gide® gives you additional safety, in cases when we have a thin phenotype and we utilize a non-resorbable membrane for GBR, and it can protect and give additional support to soft tissues and protect the surgical area in a case of a small exposure.”

– Prof. Darko Bozic | Zagreb, Croatia

“The unique properties of Geistlich Bio-Gide® provide early vascularization of the membrane, a key step in bone and periodontal regeneration.”

– Dr. Diego Capri | Bologna, Italy

“Geistlich Bio-Gide® Compressed combines alternative handling with the proven outstanding biofunctionality of Geistlich biomaterials, giving surgeons more choice for their membranes.”

– Prof. Dr. Istvan Urban | Budapest, Hungary

“Geistlich Bio-Gide® Shape is a user-friendly product that can easily be implemented in the management of post-extraction sites for ridge preservation.”

– Dr. Daniele Cardaropoli | Torino, Italy

Frequently Asked Questions

Why is a membrane necessary?

Alveolar bone regenerates best with a membrane designed for guided bone regeneration. The use of a membrane leads to increased bone as well as better quality bone compared to procedures that do not include a membrane.1

  1. Schwarz F, et al.: Clin Oral Impl Res 2008; 19(4): 402-15.

How long should a membrane function as a barrier in Guided Bone Regeneration?

Expert clinicians have estimated that a membrane used in Guided Bone Regeneration should maintain its barrier function until the provisional matrix and woven bone are present. Barrier duration is considered to be necessary for 7 to 14 days in most cases. Optimal barrier function now means that occlusiveness is maintained until the wound heals – a process which normally takes about 2 weeks.

Geistlich Bio-Gide® has proven to support bone regeneration on an equivalent level as membranes with a longer barrier function, with a reduction of complications during wound healing.1-3

  1. Tal H, et al.: Clin Oral Implants Res 2008; 19(5): 295-302.
  2. Becker J, et al.: Clin Oral Implants Res 2009; 20(7): 742-49.
  3. Schwarz F, et al.: Clin Oral Implants Res 2008; 19(4): 402-15.

How does Geistlich Bio-Gide® differ from other collagen membranes?

Geistlich Bio-Gide® is a membrane with a unique bilayer structure. It combines optimal bone formation with complication-free wound healing and predictable outcomes. The native collagen of Geistlich Bio-Gide® leads to significantly less soft tissue dehiscences compared to artificially cross-linked membranes.1 A significant number of scientific publications and proven long-term clinical success support the safety and efficacy of Geistlich Bio-Gide®.

  1. Tal H, et al.: Clin Oral Impl Res 2008; 19: 295-302.

Have inflammatory reactions been associated with Geistlich Bio-Gide®?

Inflammation is a possible complication, which may occur with any surgery. However, biocompatibility of Geistlich Bio-Gide® has been verified in numerous studies.

Is it possible to have an allergic reaction to Geistlich Bio-Gide®?

As Geistlich Bio-Gide® is made of collagen, allergic reactions and inflammatory tissue reactions cannot be excluded. However this is extremely rare.

What happens if the Bio-Gide® membrane is applied with the rough surface towards the soft tissue?

The bilayer structure of Geistlich BioGide® has a compact and porous surface. The compact layer of Geistlich Bio-Gide® exhibits higher cell occlusiveness than the rough, porous layer, preventing the downgrowth of epithelial cells. If the membrane is applied with the porous surface placed toward the soft tissue, integration of the bone cells may take place more slowly. However, it is not necessary to remove the membrane.

Can Geistlich Bio-Gide® be re-sterilized?

No. Autoclaving or hot-air sterilization irreversibly destroys the collagen structure. The physical properties of the membrane are changed and the consistency of the product becomes like parchment paper. In addition the product is not approved for re-sterilization and therefore may not be used.

Does the Geistlich Bio-Gide® membrane have to be fixed?

As Geistlich Bio-Gide® adheres very well to the defect, it is normally not necessary to utilize fixation screws or pins. However, fixation is possible if required.

How can Geistlich Bio-Gide® be used in extraction socket management for open healing?

Geistlich Bio-Gide® can be used submerged or in an open healing situation1depending on the surgeon’s preference. The advantages of the secondary intention healing of Geistlich Bio-Gide® include the ability to perform a flapless surgery and the preservation of the mucogingival line.

  1. Cardaropoli D, et al.: Int J Periodontics Restorative Dent 2012, 32(4): 421-30.

What is the difference between the two collagen membranes Geistlich Bio-Gide® Compressed and Geistlich Bio-Gide®?

Geistlich Bio-Gide® Compressed has a smoother surface, a firmer feel and is easier to cut compared to Geistlich Bio-Gide®. It offers an alternative handling for clinicians who prefer a firmer membrane. 

Does Geistlich Bio-Gide® Compressed need to be stabilized?

As Geistlich Bio-Gide® Compressed adheres very well to the defect, it is normally not necessary to stabilize with screws, pins or sutures. However, stabilization with screws, pins or sutures is possible due to its high tensile strength and may be indicated to avoid displacement due to shear loading or mobilization.

Does the smoother surface of the collagen membrane Geistlich Bio-Gide® Compressed (compared to Geistlich Bio-Gide®) affect wound healing?

The smooth surface of Geistlich Bio-Gide® Compressed does not affect wound healing. It has the same clinical performance and biological properties as Geistlich Bio-Gide®. Various studies have shown that the Geistlich Bio-Gide® family of products supports excellent wound healing1-3 and predictable bone regeneration4.

  1. Tal H, et al.: Clin. Oral Implants Res 2008; 19: 295-302. 
  2. Zitzmann NU, et al.: Int J Oral Maxillofac Implants 1997; 12: 844-52. 
  3. Becker J, et al.: Clin. Oral Implants Res 2009; 20(7): 742-93. 
  4. Schwarz F, et al.: Clin Oral Implants Res. 2014, 25(9): 1010-15.

What happens if the Geistlich Bio-Gide® Compressed membrane is applied upside down (dense surface facing the bone, porous surface facing the soft-tissue)?

The bilayer structure of Geistlich Bio-Gide® Compressed has a compact, porous surface that exhibits higher cell occlusiveness than the rough, porous layer which prevents the downgrowth of epithelial cells. If the membrane is applied with the porous surface placed toward the soft-tissue, integration of the bone cells may take place more slowly, however the membrane does not need to be removed.

What is the difference between Geistlich Bio-Gide® Shape and Geistlich Bio-Gide®?

Geistlich Bio-Gide® Shape shares the same biological properties but is pre-cut to reduce preparation time, facilitate easier handling and specifically designed for non-intact extraction sockets.

How should Geistlich Bio-Gide® Shape be placed?

Place the membrane without pre-wetting within the extraction socket. The long wing of the Geistlich Bio-Gide® Shape should be placed to cover the bony defect of the socket with the dense surface facing towards the soft-tissue and the rough side facing the defect. To close the extraction socket, both lateral wings of the Geistlich Bio-Gide® Shape membrane should be tucked underneath the mucosa, located mesially and distally of the socket. The upper wing should be tucked lingually/palatally in-between the soft-tissue and bone wall.

Should Geistlich Bio-Gide® Shape be placed inside or outside the alveolus?

The membrane can be placed inside the alveolus for a less invasive surgical procedure but can also be placed outside, between the bone and the soft-tissue. The long wing of the Geistlich Bio-Gide® Shape should cover the bony defect of the socket, if present, with the dense surface facing towards the soft-tissue, and the rough side facing the defect.

Can Geistlich Bio-Gide® Shape be sutured?

Suturing of Geistlich Bio-Gide® Shape on top may be indicated to avoid its displacement due to shear loading or mobilization. 

When should Geistlich Bio-Gide® Shape be used versus Geistlich Mucograft® Seal?

Geistlich Bio-Gide® Shape is indicated for the treatment of non-intact extraction sockets. Geistlich Mucograft® Seal is recommended in extraction sockets with intact buccal bone walls.1

  1. Geistlich Mucograft Seal Advisory Board Meeting Report, 2013. Data on file, Geistlich Pharma AG, Wolhusen, Switzerland.

What is the difference between Geistlich Bio-Gide® Perio and Geistlich Bio-Gide®?

The surface of Geistlich Bio-Gide® Perio has been made firmer when dry to facilitate periodontal applications. Second, the outer blister pack of Geistlich Bio-Gide® Perio includes four sterile water repellent templates. These can be placed repeatedly in the region of the defect to allow customization of the template before trimming the membrane to the precise shape.

Have inflammatory reactions been associated with Geistlich Bio-Gide® Perio?

Inflammation is a possible complication, which may occur with any surgery. However, the biocompatibility of Geistlich Bio-Gide® Perio has been verified in clinical studies and the incidence of complications is low.

Is it possible to have an allergic reaction to Geistlich Bio-Gide® Perio?

As Geistlich Bio-Gide® Perio is made of collagen, allergic and inflammatory tissue reactions cannot be excluded. However, this is extremely rare.

What happens if the Geistlich Bio-Gide® Perio membrane is applied with the rough surface towards the soft tissue?

The bilayer structure of Geistlich Bio-Gide® Perio has a compact and porous surface. The compact layer of Geistlich Bio-Gide® Perio exhibits higher cell occlusiveness than the rough, porous layer, preventing the downgrowth of epithelial cells. If the membrane is applied with the porous surface placed toward the soft tissue, integration of the bone cells may take place more slowly. However, it is not necessary to remove the membrane.

Can Geistlich Bio-Gide® Perio be re-sterilized?

No. Autoclaving or hot-air sterilization irreversibly destroys the collagen structure. The physical properties of the membrane are changed and the consistency of the product becomes like parchment paper. In addition the product is not approved for re-sterilization and therefore may not be used.

Does the Geistlich Bio-Gide® Perio membrane have to be secured with fixation screws or pins?

As Geistlich Bio-Gide® Perio adheres very well to the defect, it is normally not necessary to utilize fixation screws or pins. However, fixation is possible if required.

Resources

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Geistlich Membrane Brochure
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Geistlich Bio-Gide® Sell Sheet
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  1. iData Research Inc., US Dental Bone Graft Substitutes and other Biomaterials Market, 2015.
  2. iData Inc., European Dental Bone Graft Substitutes and other Biomaterials Market, 2015.
  3. Schwarz F, et al.: Clin Oral Implants Res 2006; 17: 403-09.
  4. Schwarz F, et al.: Clin Oral Implants Res 2008; 19(4): 402-15.
  5.  Jung RE, et al.: Clin Oral Implants Res. 2013; 24(10):1065-73.
  6. Rothamel D et al. Clin Oral Implants Res. 2005 Jun;16(3):369-78 (pre-clinical study)
  7. Tal H, et al.: Clin. Oral Implants Res 2008; 19: 295-302.
  8. Zitzmann NU, et al.: Int J Oral Maxillofac Implants 1997; 12: 844-52.
  9. Becker J, et al.: Clin. Oral Implants Res 2009; 20(7): 742-93.
  10. Rothamel D et al. Clin Oral Implants Res. 2005 Jun;16(3):369-78 (pre-clinical study)
  11. Schwarz F et al. Clin Oral Implants Res. 2006 Aug;17(4):403-9 (pre-clinical study)
  12. Tal H et al. Clin Oral Implants Res. 2008 Mar;19(3):295-302 (clinical study)
  13. Zitzmann NU et al. Int J Oral Maxillofac Implants 1998 Jul-Aug;13(4):576 (clinical study)
  14. Rothamel D et al. Clin Oral Implants Res. 2004 Aug;15(4):443-9 (pre-clinical study)