Request information on Trial & Observation Program (TOP)

*Terms and Conditions: Valid July 1–December 31, 2024. Each trial is limited to a total of 4 units of biomaterial, of which, one unit can be GEM 21S. Only valid for new customers or a new product category to existing customers. Excludes Yxoss, RPM, Meta, and McBio products. Not applicable for Dental Service Organizations, Government, and Military Accounts. Submission and feedback form must be submitted for qualification. Each rep is limited to 6 Trials for private practice programs and 6 Trials for university programs.

Does it Matter
which bone substitute
you choose?

How does your bone substitute stack up?

Because not all bone substitutes and manufacturers are created equal, there are several characteristics to consider that can lead to successful graft outcomes. How does your current bone substitute compare? Below are key characteristics to consider and why they are important:


Selecting the right xenograft with specific features is crucial for a successful outcome. What to consider:

Geistlich Bone
Substitute Portfolio

Your Current
Bone Substitute

Resorption Rate & Volume Stability

Once the tooth is gone, the alveolar bone resorbs over time. If the bony defect is augmented with a slow resorption bone substitute material, the volume of the augmented area will be preserved over the long-term yielding to stable functional and esthetic results.

The slow resorption of Geistlich Bio-Oss® and the ideally matched protective function of Geistlich Bio-Gide® promote the long-term volume stability1 of the augmentation material and ensure high implant survival rates.2

Processing Technique & Pore Structure

Processing is a critical factor to consider when choosing a bone substitutes manufacturer because it directly affects the quality, safety, and effectiveness of bone substitute products.

Geistlich Bio-Oss® undergoes a patented processing technique to preserve the natural integrity of the graft.

    Geistlich Bio-Oss Key Processing Steps:
  1. Cleaning
  2. Cutting
  3. Deproteinization
  4. Drying

This patented process leads to a unique interconnecting pore system, which is highly similar to human bone, an ideal environment for forming new bone.3

Handling Needs

For precision, ease of use, and adaptability, variation of handling properties is essential.

Geistlich offers a wide variety of handling needs from granules, to Geistlich Bio-Oss Collagen® to Geistlich Bio-Oss Pen®. Geistlich Bio-Oss Pen® enables you to access hard to reach areas of the mouth, while not compromising on ergonomics. Geistlich Bio-Oss Collagen® provides easy to hydrate and to position right in the defect area.


When selecting an allograft, it is essential to consider various characteristics to ensure the best possible outcomes. What to consider:

Geistlich Bone
Substitute Portfolio

Your Current Bone

Processing Matters

Processing is a critical factor to consider when choosing an allograft because it directly affects the quality, safety, and effectiveness of the tissue.

vallos® undergoes a unique patented processing technique to preserve the integrity of the graft.

    vallos® MTF Difference:
  1. Stringent Donor Selection — Less than 2% of all donated tissue is accepted.4
  2. Rigorous Testing — MTF is the only tissue bank to use The Vanguard Method® that exceeds industry standards.
  3. 100% Aseptic Processing — Preserves inherent biologic and structural properties. Leads to an unmatched tissue integrity and is naturally biocompatible with recipient.

Leads to the most natural tissue and exceptional biocompatibility with the recipient.

Variety of Configurations for the Right Indication

Flexibility within the portfolio to meet all your patient and surgical needs with the convenience of a single source provider.

By the numbers, Geistlich offers 35 allograft variations. vallos® consists of 9 configurations (four demineralized and five mineralized forms) in various cortical | cortico-cancellous | cancellous formulations.

Handling Needs

For precision, ease of use, and adaptability, variation of handling properties is essential.

Looking for handling? vallos®f demineralized Interwoven three dimensional fibers retain a putty like consistency that is packable and conforms to the shape of the defect.

Verified Osteoinductivity

Osteoinductivity of allografts can be impacted by both processing and sterilization methods, such as gamma irradiation which has been well documented to reduce the osteoinductive potential up to 50%.4 It is important that the osteoinductive potential is assessed post processing to ensure that it’s representative of the final product.5

Each and every lot of vallos® demineralized is tested for osteoinductivity potential, including BMP-2 post processing.


The choice of manufacturer is an important consideration when selecting bone substitute because it directly impacts the quality, support, and reliability.

Geistlich Bone
Substitute Portfolio

Your Current Bone

Manufacturing Ownership

Where is the bone substitute sourced?

Geistlich controls and manufactures Geistlich Bio-Oss® from the beginning to end. All vallos® allografts come from our single source provider, MTF, to ensure consistent product quality.

Long Term Clinical Evidence

Evaluating the success of a treatment is a function of time, so analyzing the companies’ long-term clinical evidence is critical in understanding the effectiveness of the bone substitutes.

Geistlich has led the guided bone regeneration world for more than 35 years, with 24+ years of independent clinical follow up.6

MTF brings 35+ years experience, 150,000+ tissue donors processed, and 10M grafts provided.

Peer-Reviewed Literature

Worldwide Independent research groups proving safety and efficacy of products and treatments.

Geistlich has more than 1,400 published peer-reviewed literature.

Cost-Benefit Analysis:

Analyze the cost-effectiveness of the bone substitute, taking into account the initial cost, potential complications, and the long-term benefits it offers compared to other treatment options.

Learning Opportunities and Resources

The ability to touch and feel the products, enhance your skills, and expertise to provide the assurance and continuous learning.

Key users

Key users can share data and insights about patient outcomes associated with various bone substitute products. This information is valuable in assessing the long-term effectiveness of different materials.

  1. Mordenfeld A et al.: Clin Oral Implants Res 2010; 21 (9), 961-70.
  2. Jung RE et al.: Clin Oral Implants Res 2013; 24 (10), 1065-73.
  3. Berglundh, T. et al. (1997). Clin Oral Implants Res. 8(2): 117–124.
  4. Data on file, MTF Biologics
  5. Gertzman AA, Sunwoo M, Raushi D, Dunn M. The Effect of Cold Gamma Radiation Sterilization on the Properties of Demineralised Bone Matrix. In: Kennedy JF, Philips GO, Williams PA, editors. Sterilization of tissues using ionising radiations: CRC Press; 2005. p 151-156.
  6. Jung R, et al., Clin Oral Implants Res 2021 Dec; 32(12):1455-1465.

The use of Geistlich Bio-Oss® resulted in significantly lower number of implant losses, compared to autogenous bone particles and other bone-graft materials.1