Fundamentally, the use of small particles is recommended for small defects (up to 2 dental alveoli) and for augmenting autogenous grafts. The large particles are recommended for large defects (> 2 dental alveoli, sinus lifts), however, preferences can vary from dentist to dentist.

A membrane should be used in conjunction with Geistlich Bio-Oss^® or Geistlich Bio-Oss Pen^® as a barrier against the ingrowth of soft tissue¹. Native collagen membranes such as Geistlich Bio-Gide^® also promote wound healing and increase therapeutic safety in the event of a postoperative wound dehiscence^2,3. Clinicians should read the package insert prior to use.

1. Gielkens PF, et al.: Clin Oral Implants Res 2008; 19(5) : 516-21. 
2. Tal H, et al.: Clin Oral Implants Res 2008; 19(3): 295-302. 
3. Becker J, et al.: Clin Oral Implants Res 2009; 20(7): 742-49

No. If Geistlich Bio-Oss^® is autoclaved, moisture can collect in the particles due to the high porosity of the product, which can change the hydrophilic properties. Moreover, Geistlich Bio-Oss^® is not approved for re-sterilization. Re-sterilization under any circumstances is not recommended.

The use of local antibiotics is generally unnecessary when utilizing Geistlich Bio-Oss^®.

Geistlich Bio-Oss^® is made from the mineral part of bovine bone. The strictly controlled manufacturing process ensures high quality and safety standards by:

• country of origin: Switzerland, Australia (and for some countries also New Zealand), which is historically and currently free of BSE
• defined origin of the raw material
• selected and certified slaughterhouses
• pre- and post-mortem health inspection for each individual animal
• extremity bone (according to WHO Guideline on tissue infectivity classified as tissues with no detected infectivity or infectious prions)
• effective inactivation methods with 15h treatment at high temperature and cleaning with strong alkaline solutions
• sterilization, double sterile packaging
• official controls by international authorities

Blood from the defect may be used for mixing. Care should be taken to avoid contamination with salivary bacteria.

0.25 cc Geistlich Bio-Oss Pen^®: ~0.25 ml
0.5 cc Geistlich Bio-Oss Pen^®: ~0.5 ml

Depending on the size of the defect, between 1.5 to 4 cc of Geistlich Bio-Oss^® granules are needed, 3cc on average.

No, Geistlich does not recommend mixing autologous bone with the Geistlich Bio-Oss^® granules within the syringe.

No. Discard and use a new Geistlich Bio-Oss Pen^®.

No. The applicator tips are not available separately.

No. There are no other tips available.

The IFUs for Geistlich products can be found using this page.