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GEM 21S^®, the first recombinant growth factor product for use in oral regenerative surgery. Learn More

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Use the search and filter form below to find informative clinical content by format, therapeutic areas, or product.

FEATURED RESOURCE

Therapeutic Areas
- Minor Bone Augmentation(1)
- Peri-Implantitis(1)
- Periodontal Regeneration(6)
- Ridge Preservation(3)
- Soft-Tissue Regeneration(3)
Products
- Geistlich Bio-Gide®(1)
- Geistlich Bio-Oss Collagen®(1)
- Geistlich Bio-Oss®(2)
- Geistlich Fibro-Gide®(1)
- GEM 21S®(16)
- vallos®(2)
- vallos®f(1)

Found 16 Results

Baseline Radiograph

Baseline ≥ 10 mm Pocket Depth

Geistlich Bio-Gide® covering bone graft and soaked in rhPDGF-BB

Suturing with 5/0 nylon sutures. Primary closure attained.

Radiograph at 10-year follow-up

Clinical situation at 10 years

Pre-operative Condition

Bone graft placement, saturated with rhPDGF-BB

Collagen membrane placement

After six months, healing was complete, resulting in a 10×10×6.5 mm bone fill. Tooth #7, which was part of the combined defect, was fully regenerated.

The adjacent ridge defect was also restored, enabling the placement of a standard-sized implant without the need for additional grafting.

Andrea Ravidà, DDS, MS, PhD
Anu Viswanathan DDS, MDS

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Prosthetic-Surgical Approach to Regenerative Treatment for Peri-Implantitis

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Clinical presentation of tooth #31 showing radiographic evidence of bone loss, profuse bleeding on probing (BOP), deep probing depths, and suppuration, indicative of peri-implantitis with a Class I-infraosseous (c) circumferential-type defect, as described in the study by Monje et al. (2019) Clin Implant Relat Res, 21(4)635-643.

Crown removal by the prosthodontist, followed by placement of a healing abutment for non-surgical therapy using PerioFlow®. After therapy, a cover screw was placed, and the tissue was allowed to heal over the implant for eight weeks.

Surgical treatment initiated with a midcrestal incision and full-thickness flap elevation. Granulation tissue was removed using a surgical curette, revealing a deep infrabony defect.

Implant thoroughly decontaminated using Perioflow® with erythritol powder to ensure a clean surface for regeneration.

rhPDGF-BB was used to hydrate bone grafting materials (vallos® Demineralized Cortical Granules and Geistlich Bio-Oss®), which were first hydrated with sterile water before rhPDGF-BB was added. The materials were mixed in a 1:1 ratio and allowed to sit for 10 minutes before being applied to the deep infrabony defect to promote regeneration.

Flap closed primarily with 5-0 PTFE horizontal mattress and single interrupted suture for secure closure.

Collagen membrane stabilized with 5-0 chromic gut sutures using the lasso technique.

After 5 months of healing, significant bone gain is evident. Geistlich Bio-Oss® was placed on the buccal site to enhance thickness, covered with an amnion-chorion membrane. A healing abutment was placed at this stage.

Two-year follow-up shows disease resolution with shallow probing depths, no bleeding or suppuration, and complete bone gain. A new crown was fabricated with an increased final abutment height (>2mm), contributing to optimal maintenance and long-term stability based on evidence supporting its role in promoting long-term success. A second surgery may be necessary to gain additional tissue thickness or cover residual thread exposure to achieve the desired long-term results.

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