Patients are unpredictable.
GEM 21S® delivers predictable growth.
Consistent outcomes powered by rhPDGF, no matter the case.
Every clinician knows the reality: no two patients heal the same.
Differences in age, health, and clinical presentation introduce variability that can make regenerative outcomes difficult to predict—even with meticulous technique. Yet predictability is exactly what clinicians strive for when planning and executing regenerative procedures. This eBook explores evidence backed science to achieve consistent, predictable outcomes.
Predictability
Delivers consistent, predictable outcomes powered by its 10,000X concentration of PDGF.1,2
Rapid Response
rhPDGF predictably and dramatically enhances the ingrowth of regenerative stem cells into your grafts within 72 hours.1,3
Regenerative Power
rhPDGF significantly increases the proliferation and migration of osteoblasts and other key cells of the periodontium.4-6
Clinical Confidence
Evidence-backed results mean less guesswork, more certainty for every patient.
Streamlined Workflow
Predictable healing supports faster, more efficient procedures and improved patient satisfaction.
How to Reduce Variability and Achieve Predictable Regeneration
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Include GEM 21S® in your regenerative regimen today!
Hard and Soft Tissue Performance.
Clinically Proven.
Soft Tissue
A randomized controlled trial showed that Geistlich Fibro-Gide® combined with rhPDGF-BB may promote faster healing, reduced inflammation, and improved soft-tissue stability and volume.7
Bone
rhPDGF-BB has been shown to support enhanced bone regeneration with greater vital bone formation.8
Testimonials
“In dealing with periodontal defects, one of my favorite biomaterials to use is GEM 21S® which is highly purified recombinant human platelet-derived growth factor (rhPDGF-BB).”Dr. John Kim, DMD, MS, PA
A Heritage of Innovation
Since 1851, Geistlich has been at the forefront of biomaterial science, developing safe and naturally sourced solutions that dental professionals trust worldwide. Our commitment to innovation stems from generations of Swiss precision and scientific excellence, making us the preferred choice for clinicians who demand the highest standards of quality and reliability.
- Castillo, 2011 AM J Sports Med
- Kobayashi, Eiz 2016, Clinical Oral Investigation, Vol 20, 2353-2360.
- Choukroun, et al. 2006 Oral Surg Oral Med Oral Pathol Oral Radiol Endod
- Wang HL, Pappert TD. Castelli WA, Chiego DJ Jr., Shyr Y, Smith BA, The Effect of Platelet-Derived Growth Factor on the Cellular Response of the Periodontium: An Autogradiographic Study on Dogs. J Periodontal. 1994 May; 65 (5): 429-36.
- Graves DT. The Use of Biologic Response Modifiers in Human Clinical Trials. Ann Periodontol. 1997; 2: 259-267.
- Piche JE, Graves DT. Study of the Growth Factor Requirements of Human Bone-Derived Cells: a Comparison with Human Fibroblasts. Bone. 1989; 10(2): 131-189.
- Tavelli et al., 2025 – Journal of Periodontal Research
- Wallace et al., 2013 – PubMed PMID: 23998156
GEM 21S® has not been approved by the FDA for use with Geistlich Fibro-Gide and soft tissue in the US and the safety and effectiveness of GEM 21S for this use has not been established by FDA.
